Active Ingredient Coenzyme Q10

presence during reconstitution of acetylcholine receptor into phospholipid vesicles yields vesicles active in catalyzing carbamylcholine-sensitive na+ flux;

Source:

medlineplus herbs and supplements: coenzyme q10

Medical Condition	Uses based on scientific evidence	Grade*
acute myocardial infarction	there is preliminary human study of coq10 given to patients within three days after a heart attack. better research is needed before a firm conclusion can be drawn.	c
acute renal failure	there is initial data to support the use of coq10 in the treatment of kidney (renal) failure. more research is needed before a recommendation can be made.	c
alzheimer's disease	promising preliminary evidence suggests that coq10 supplements may slow down, but not cure, dementia in people with alzheimer's disease. additional well-designed studies are needed to confirm these results before a firm recommendation can be made.	c
asthma	coq10 may benefit asthma patients when added to other therapies. further research is needed. asthma should be treated by a qualified healthcare provider.	c
cardiomyopathy	there is conflicting evidence from research on the use of coq10 in patients with dilated or hypertrophic cardiomyopathy. better research is needed in this area before a recommendation can be made.	c
chronic fatigue syndrome	early study shows that coq10 may improve symptoms of chronic fatigue syndrome. high quality research is needed in this area before a decision can be made.	c
chronic ischemic heart disease unspecified	there is not enough scientific evidence to recommend for or against the use of coq10 in patients with coronary heart disease.	c
cocaine dependence	a combination of coenzyme q10 and l-carnitine has been studied to reduce cocaine usage, but early study is inconclusive.	c
diabetes mellitus without mention of complication	preliminary evidence suggests that coq10 does not affect blood sugar levels in patients with type 1 or type 2 diabetes, and it does not alter the need for diabetes medications.	d
disorders of mitochondrial metabolism	coq10 is often recommended for patients with mitochondrial diseases, including myopathies, encephalomyopathies, and kearns-sayre syndrome. better studies are needed before a strong recommendation can be made.	c
friedreich's ataxia	preliminary research reports promising evidence for the use of coq10 in the treatment of friedreich's ataxia. further evidence is necessary before a firm conclusion can be drawn.	c
heart failure	there is early data to support the use of coq10 in children with mitral valve prolapse. well-designed clinical trials are needed before a recommendation can be made.	c
heart failure	the evidence for coq10 in the treatment of heart failure is controversial and remains unclear. different levels of disease severity have been studied (new york heart association classes i through iv). better research is needed in this area studying the effects on quality of life, hospitalization, and death rates before a recommendation can be made.	c
hereditary progressive muscular dystrophy	preliminary studies in patients with muscular dystrophy taking coq10 supplements describe improvements in exercise capacity, heart function, and overall quality of life. additional research is needed in this area.	c
human immunodeficiency virus (hiv) disease	there is limited evidence that natural levels of coq10 in the body may be reduced in people with hiv/aids. there is a lack of reliable scientific research showing that coq10 supplements have any effect on this disease.	c
huntington's chorea	there is negative evidence from studies that used coq10 in the treatment of huntington's disease.	d
macular degeneration (senile) of retina unspecified	early study shows that acetyl-l-carnitine, n-3 fatty acids, and coenzyme q10 (phototrop ) may help age-related macular degeneration. more research is needed using coenzyme q10 alone before a recommendation can be made.	c
malignant neoplasm of female breast	supplementation with coq10 has not been proven to reduce cancer and has not been compared to other forms of treatment for breast cancer.	c
malignant neoplasm of prostate	one study using a combination that included coq10 did not find a significant effect on psa levels in patients with prostate cancer. although psa levels may be an indicator of cancer, it is unclear whether coq10 would have any effect on cancer treatment of prevention. more study is needed.	c
migraine	there is fair evidence to support the use of coq10 treatment in migraine prevention or treatment. however, more well-designed studies are needed to confirm these findings.	c
neoplasm of uncertain behavior of other lymphatic and hematopoietic tissues	further research is needed before a recommendation can be made. early study results are unclear.	c
neoplasms	further research is needed to determine if coq10 may help cancer when used with other therapies. cancer should be treated by a qualified healthcare provider.	c
other and unspecified angina pectoris	preliminary small human studies suggest that coq10 may reduce angina and improve exercise tolerance in people with clogged heart arteries. better studies are needed before a firm recommendation can be made.	c
other specified complications of procedures not elsewhere classified	in patients with stage i and ii melanoma with surgically removed lesions, coq10 may decrease the rate of recurrence. although these results are promising, more study is needed in this area to confirm these conclusions.	c
parkinson's disease	there is promising human evidence for the use of coq10 in the treatment of parkinson's disease. better-designed trials are needed to confirm these results.	c
pure hyperglyceridemia	early study of coq10 for high triglyceride levels in the blood is unclear.	c
tinnitus	more research is needed in patients with tinnitus with low levels of coq10 before a strong recommendation can be made.	c
unspecified essential hypertension	preliminary research suggests that coq10 causes small decreases in blood pressure (systolic and possibly diastolic). low blood levels of coq10 have been found in people with hypertension, although it is not clear if coq10 "deficiency" is a cause of high blood pressure. well-designed long-term research is needed to strengthen this recommendation.	b
unspecified gingival and periodontal disease	preliminary human studies suggest possible benefits of coq10 taken by mouth or placed on the skin or gums in the treatment of periodontitis. better research is needed before a strong conclusion can be drawn.	c

*Key to grades
A: Strong scientific evidence for this use;
B: Good scientific evidence for this use;
C: Unclear scientific evidence for this use;
D: Fair scientific evidence against this use;
F: Strong scientific evidence against this use.