Active Ingredient Creatine

an amino acid that occurs in vertebrate tissues and in urine. in muscle tissue, creatine generally occurs as phosphocreatine. creatine is excreted as creatinine in the urine.

Source:

medlineplus herbs and supplements: creatine

Medical Condition	Uses based on scientific evidence	Grade*
acute myocardial infarction	there is early evidence that intravenous creatine after a heart attack may be beneficial to heart muscle function and may prevent irregular heart rhythms. further study is needed before a recommendation can be made in this area. it has been reported that the use of creatine phosphate may have a favorable effect on mental deterioration in "cardio-cerebral syndrome" following heart attacks in the elderly. more research is needed.	c
amyotrophic lateral sclerosis	overall, the evidence suggests that creatine supplementation does not offer benefit to individuals with amyotrophic lateral sclerosis (als).	d
apnea	early studies of creatine in animals and humans have found mixed results in patients with a breathing disorder in infants, called apnea of prematurity. well-designed studies are needed to better understand this relationship.	c
chronic ischemic heart disease unspecified	early studies suggest a potential benefit of creatine supplements in patients undergoing coronary artery surgery. some evidence suggests that heart muscle may recover better and more rapidly after open-heart surgery if intravenous creatinine is used during the operation. larger, well-designed studies are needed before a strong recommendation can be made.	c
chronic obstructive pulmonary disease and allied conditions	it is unclear if creatine can help treat chronic obstructive pulmonary disease. study results are mixed. more clinical trials are needed before a strong recommendation can be made.	c
congestive heart failure unspecified	patients with chronic heart failure have low levels of creatine in their hearts. several studies report that creatine supplements may improve heart muscle strength, body weight, and endurance in patients with heart failure. studies comparing creatine with drugs used to treat heart failure are needed before a firm recommendation can be made. heart failure should be treated by a qualified healthcare professional.	b
depressive disorder not elsewhere classified	early research suggests a potential beneficial of creatine supplements in depression. creatine may have brought on a manic switch in patients with bipolar depression. large, well-designed studies are needed.	c
disorders of urea cycle metabolism	ornithine is normally formed in the liver. some individuals are born with a genetic disorder that prevents them from appropriately breaking down ornithine, which causes blood levels to become too high. high amounts of ornithine may lead to blindness, muscle weakness, and reduced storage of creatine in muscles and the brain. although there is only limited research in this area, early evidence suggests that long-term, daily creatine supplements may help replace missing creatine and slow vision	c
general symptoms	numerous studies suggest that creatine may help treat various neuromuscular diseases and may delay the onset of symptoms when used with standard treatment. however, creatine ingestion does not appear to have a significant effect on muscle creatine stores or high-intensity exercise capacity in individuals with multiple sclerosis and supplementation does not seem to help people with tetraplegia.although early studies were encouraging, recent research reports no beneficial effects on survival or	c
glycogenosis	in mcardle's disease, there is a deficiency of energy compounds stored in the muscles. this leads to muscle fatigue, exercise intolerance, and pain when exercising. creatine has been proposed as a possible therapy for this condition. however, research is limited, and the results of existing studies are mixed. therefore, it remains unclear if creatine offers any benefits to patients with mcardle's disease.	c
hereditary progressive muscular dystrophy	creatine loss is suspected to cause muscle weakness and breakdown in patients with duchenne muscular dystrophy. studies with creatine have found mixed results for this condition. further research is needed before a strong recommendation can be made.	c
huntington's chorea	there is not enough scientific information to make a firm recommendation about the use of creatine in huntington's disease. high-quality studies are needed to clarify this relationship.	c
ischemic heart disease	early high-quality studies suggest a potential benefit of creatine in people with ischemic heart disease. more clinical trials are needed before a firm recommendation can be made.	c
memory loss	early studies show that creatine may improve cognition in certain populations, such as vegetarians and the elderly. further research is required before recommendations can be made.	c
multiple sclerosis	early study suggests that creatine supplementation does not improve work production in people with multiple sclerosis. however, large, well designed studies are required before a strong recommendation can be made.	c
other and unspecified complications of medical care not elsewhere classified	early studies suggest that creatine does not lower homocysteine levels in chronic hemodialysis patients. however, these patients were also using vitamin b12 and folate. muscle cramps are also common complications of hemodialysis. creatine may offer some benefit for this side effect. however, studies in which creatine alone is compared with placebo are needed.	c
other disorders of bone and cartilage	early studies examining the effect of creatine in aging suggest that creatine may increase bone density when combined with resistance training. further studies in which creatine alone is compared with placebo are needed.	c
other musculoskeletal symptoms referable to limbs	several high-quality studies have shown an increase in muscle mass with the use of creatine. however, some weaker studies have reported mixed results. overall, the available evidence suggests that creatine does increase lean body mass, strength, and total work. future studies should take into account the effect of different individual fitness levels of study subjects.	a
pure hypercholesterolemia	early studies did not find a benefit of creatine in the treatment of high cholesterol. more studies are needed before a clear conclusion can be drawn.	c
unspecified site of spinal cord injury without spinal bone injury	it is unclear if creatine is helpful in patients with spinal cord injuries. results from early studies have been mixed. further studies are required before a firm recommendation can be made.	c

*Key to grades
A: Strong scientific evidence for this use;
B: Good scientific evidence for this use;
C: Unclear scientific evidence for this use;
D: Fair scientific evidence against this use;
F: Strong scientific evidence against this use.