Active Ingredient Omega-3 Fatty Acids, Fish Oil, Alpha-linolenic Acid

a vitamin-like antioxidant.

Source:

medlineplus herbs and supplements: omega-3 fatty acids, fish oil, alpha-linolenic acid

Medical Condition	Uses based on scientific evidence	Grade*
angina pectoris	early studies report reductions in chest pain (called angina) associated with fish oil intake. better research is necessary before a firm conclusion can be drawn.	c
asthma	several studies in this area do not provide enough reliable evidence to form a clear conclusion, with some studies reporting no effects, and others finding benefits. because most studies have been small without clear descriptions of design or results, the results cannot be considered conclusive.	c
atherosclerosis	some research reports that regular intake of fish or fish oil supplements reduces the risk of developing atherosclerotic plaques in the arteries of the heart, while other research reports no effects. additional evidence is necessary before a firm conclusion can be drawn in this area.	c
attention deficit disorder of childhood with hyperactivity	there is evidence that polyunsaturated fatty acids (pufas) may help treat adhd-related problems, including inattention, hyperactivity, and impulsivity. more research is needed to confirm these findings.	c
bipolar disorder, other	it is unclear if omega-3 fatty acids can help improve symptoms of bipolar disorder. study results are mixed.	c
cardiac dysrhythmia unspecified	there is promising evidence that omega-3 fatty acids may decrease the risk of irregular heartbeats (called cardiac arrhythmias). it is possible that this action may be responsible for reducing the number of heart attacks in people who regularly ingest fish oil or epa + dha. in patients with defibrillators, there is emerging evidence that fish oil supplementation may not be safe, and its effectiveness has been questioned. additional research is needed in this area before a firm conclusion can be	c
cardiovascular disease unspecified	several studies report that regular consumption of oily fish or fish oil/omega-3 supplements reduces the risk of non-fatal heart attacks, fatal heart attacks, sudden death, and deaths due to any cause in people with histories of heart attacks. most patients in these studies were also using standard heart drugs, suggesting that the benefits of fish oils may add to the effects of other therapies.	a
cardiovascular disease unspecified	several large studies of populations (called epidemiological studies) report a significantly lower rate of death from heart disease in people who regularly eat fish. other epidemiological research reports no such benefits. it is unclear if benefits only occur in certain groups of people, such as those at risk of developing heart disease. fish oil is also associated with improved blood vessel functioning and decreased resting heart rate. overall, the evidence suggests benefits of regular	b
cardiovascular disease unspecified	additional research is necessary before a conclusion can be drawn in this area.	c
cardiovascular disease unspecified	several randomized controlled trials have examined the effects of alpha-linolenic acid in people with histories of heart attacks. although some studies suggest benefits, others do not. additional research is needed before a conclusion can be drawn in this area.	c
cerebral artery occlusion unspecified with cerebral infarction	several large studies of populations (called epidemiological studies) have tested the effects of omega-3 fatty acid intake on stroke risk. some studies suggest benefits, while others do not. effects are likely on ischemic or thrombotic stroke risk, and very large intakes of omega-3 fatty acids ("eskimo" amounts) may actually increase the risk of hemorrhagic (bleeding) stroke. at this time, it is unclear if there are benefits in people with or without histories of strokes or if effects of fish	c
chronic ischemic heart disease unspecified	because higher levels of omega-3 fatty acids have been shown to reduce the risk of sudden cardiac death, researchers have tested if the same is true for acute coronary syndrome (acs). early evidence suggests that people who have low levels of epa and dha may have an increased risk of developing acs. more research is needed in this area.	c
contact dermatitis and other eczema unspecified cause	it is unclear if epa can help treat eczema. more research is needed.	c
cystic fibrosis	a small amount of research in this area does not provide enough reliable evidence to form a clear conclusion.	c
dementias	well-designed clinical trials are needed before omega-3 fatty acids can be recommended for the prevention of cognitive impairment or dementia.	c
depressive disorder not elsewhere classified	low levels of omega-3 fatty acids have been linked to depression. some studies suggest that supplements may decrease suicidal behavior and improve symptoms of postpartum depression and childhood depression. however, more research is needed to confirm these early findings.	c
diabetes mellitus without mention of complication	the available scientific evidence suggests that there are no significant long-term effects of fish oil in patients with diabetes. most studies in this area are not well designed.	d
disorders involving the immune mechanism	some research suggests that fish oil supplementation during pregnancy may speed up the infant's immune system development. however, it is unclear if this affects the infant's health in the future. other research suggests that supplements during pregnancy may affect the functioning of white blood cells, called neutrophils. more research is needed to fully understand how fish oil affects the immune system.	c
dysmenorrhea	there is early evidence suggesting possible benefits of fish oil/omega-3 fatty acids in women with dysmenorrhea. additional research is needed before a firm conclusion can be reached.	c
epilepsy	in patients with chronic refractory epilepsy, a disorder that causes seizures, omega-3 supplements may improve brain energy metabolism and increase the level of phospholipids in the brain. more research is needed to determine if this is an effective treatment for patients with epilepsy.	c
hypertensive heart and kidney disease	there are many studies of heart transplant and kidney transplant patients taking cyclosporine (neoral ) who received fish oil supplements. the majority of trials report improvements in kidney function (glomerular filtration rate, serum creatinine) and less hypertension (high blood pressure) compared to patients not taking fish oil. however, several recent studies report no benefits on kidney function, and no changes have been found in rates of rejection or graft survival.	d
latent schizophrenia	early evidence suggests that omega-3 fatty acids may help improve symptoms of schizophrenia. evidence suggests that a combination of omega-3 fatty acids and antioxidants might also reduce the side effects of haloperidol, an antipsychotic medication.	c
lupus erythematosus	there is not enough reliable evidence to form a clear conclusion in this area.	c
macular degeneration (senile) of retina unspecified	it has been suggested that omega-3 fatty acids may help prevent an eye disorder, called age-related macular degeneration. however, more research is needed to confirm these early findings.	c
malignant neoplasm of rectum	cancer patients have been reported to commonly take omega-3 fatty acids. early studies report that fish oil may reduce the growth of colon cancer cells and polyps. however, it is unclear if fish oil effects cancer survival or remission.	c
mechanical complication of other specified prosthetic device implant and graft	research has shown that omega-3 fatty acids help reduce inflammation. scientists believe that their anti-inflammatory effects may help protect against heart disease.	b
mild or unspecified pre-eclampsia	if is unclear if fish oil helps treat or prevent preeclampsia in pregnant women. more research is needed.	c
neoplasms	several population (epidemiological) studies report that dietary omega-3 fatty acids or fish oil may reduce the risk of developing breast, colon, or prostate cancer. better-designed studies are necessary before a clear conclusion can be drawn.	c
nephritis and nephropathy not specified as acute or chronic with unspecified pathological lesion in kidney	there are mixed results from several trials in this area.	c
nephrotic syndrome	there is not enough reliable evidence to form a clear conclusion in this area.	c
osteoporosis	early evidence suggests that plant sources of dietary n-3 pufa may help protect against bone loss. more research is needed to confirm these findings.	c
other and unspecified noninfectious gastroenteritis and colitis	it has been suggested that omega-3 fatty acids may reduce pain and inflammation associated with inflammatory bowel disease (crohn's disease and ulcerative colitis) when added to standard therapy. however, study results are mixed, and no clear conclusion can be made at this time.	c
other current conditions complicating pregnancy childbirth or the puerperium	dha has been found to be important for healthy pregnancies. research shows that fish oil supplementation from the 22nd week of pregnancy until delivery improves the amount of n-3 lc-pufa in the fetus and the mother.	b
other disorders of prostate	early research suggests that walnuts do not affect blood levels of prostate-specific antigen (psa). psa is a marker of prostate enlargement, inflammation, and cancer.	c
other nutritional deficiencies	early evidence suggests that omega-3 fatty acid supplements may be a good source of nutrition for patients with crohn's disease or for those who need to be tube fed after abdominal surgeries.	b
other peripheral vascular disease	peripheral vascular disease (pvd) occurs when the blood vessels to the arms and legs are clogged. when the muscles do not get enough blood, it causes a type of pain, called claudication. some evidence suggests that fish oil may improve blood pressure in the legs of patients with pvd and increase how far they can walk until they feel pain. more research is needed.	c
phenylketonuria (pku)	patients with pku must follow a diet that does not contain any phenylalanine, which is found in high-protein foods, such as cheese, milk, nuts, or meats. therefore, low levels of aa and dha are common among children with pku during the first year of life. early research suggests that long chain polyunsaturated fatty acid (lcpufa) supplementation of pku diets during the first year of life improves lcpufa levels so that they are similar to those of healthy, breastfed infants.	c
polyphagia	there is early evidence that fish oil supplementation does not improve appetite or prevent weight loss in cancer patients. further study is needed.	d
psoriasis and similar disorders	several studies in this area do not provide enough reliable evidence to form a clear conclusion.	c
pure hypercholesterolemia	although fish oil is able to reduce triglycerides, beneficial effects on blood cholesterol levels have not been demonstrated. fish oil supplements appear to cause small improvements in high-density lipoprotein ("good cholesterol"); however, increases (worsening) in low-density lipoprotein levels ("bad cholesterol") are also observed. fish oil does not appear to affect c-reactive protein (crp) levels.	d
pure hyperglyceridemia	there is strong scientific evidence from human trials that omega-3 fatty acids from fish or fish oil supplements (epa + dha) significantly reduce blood triglyceride levels. benefits appear to be dose-dependent. fish oil supplements also appear to cause small improvements in high-density lipoprotein ("good cholesterol"); however, increases (worsening) in low-density lipoprotein levels (ldl/"bad cholesterol") have also been observed. it is not clear if alpha-linolenic acid significantly affects	a
rheumatoid arthritis	many studies report improvements in morning stiffness and joint tenderness with the regular intake of fish oil supplements for up to three months. fish oil has been shown to increase the effects of anti-inflammatory medications, such as nsaids (such as ibuprofen). however, because of weaknesses in study designs and reporting, better research is needed before a strong favorable recommendation can be made.	b
unspecified essential hypertension	multiple human trials report small reductions in blood pressure with intake of omega-3 fatty acid. dha may have greater benefits than epa. however, it may be necessary to take high amounts of omega-3 fatty acids per day to obtain these health benefits, and high doses may increase the risk of bleeding. therefore, a qualified healthcare provider should be consulted before starting treatment with fish oil supplements.	a

*Key to grades
A: Strong scientific evidence for this use;
B: Good scientific evidence for this use;
C: Unclear scientific evidence for this use;
D: Fair scientific evidence against this use;
F: Strong scientific evidence against this use.