Medical Condition Depressive Disorder Not Elsewhere Classified

Source:

2009 icd-9-cm diagnosis 311 - depressive disorder not elsewhere classified

Active Ingredients used for Depressive Disorder Not Elsewhere Classified:

Creatine, Dhea, Folate, Lavender, Omega 3 Fatty Acids Fish Oil Alpha Linolenic Acid, Riboflavin, St Johns Wort, Vitamin B6

Active Ingredient	Uses based on scientific evidence	Grade*
creatine	early research suggests a potential beneficial of creatine supplements in depression. creatine may have brought on a manic switch in patients with bipolar depression. large, well-designed studies are needed.	c
dhea	the majority of clinical trials investigating the effect of dhea on depression support its use for this purpose under the guidance of a specialist. further research is needed to confirm these results.	b
folate (folic acid)	folic acid deficiency has been found among people with depression and has been linked to poor response to antidepressant treatment. folate supplements have been used for enhancing treatment response to antidepressants. limited clinical research suggests that folic acid is not effective as a replacement for conventional antidepressant therapy. depression should be treated by a qualified healthcare provider.	c
lavender (lavandula angustifolia miller)	preliminary research suggests that lavender may be helpful as an adjunct to prescription antidepressant medications. additional research is necessary before a firm conclusion can be drawn.	c
omega-3 fatty acids, fish oil, alpha-linolenic acid	low levels of omega-3 fatty acids have been linked to depression. some studies suggest that supplements may decrease suicidal behavior and improve symptoms of postpartum depression and childhood depression. however, more research is needed to confirm these early findings.	c
riboflavin (vitamin b2)	adequate nutrient supplementation with riboflavin may be required for the maintenance of adequate cognitive function. treatment with b-vitamins, including riboflavin, has been reported to improve depression scores in patients taking tricyclic antidepressants. this may be related to tricyclic-caused depletion of riboflavin levels.	c
st. john's wort (hypericum perforatum l.)	st. john's wort has been extensively studied in europe over the last two decades, with more recent research in the united states. short-term studies (1-3 months) suggest that st. john's wort is more effective than placebo (sugar pill), and equally effective as tricyclic antidepressants (tcas) in the treatment of mild-to-moderate major depression. comparisons to the more commonly prescribed selective serotonin reuptake inhibitor (ssri) antidepressants, such as fluoxetine (prozac ) or sertraline	a
st. john's wort (hypericum perforatum l.)	studies of st. john's wort for severe depression have not provided clear evidence of effectiveness.	c
vitamin b6	preliminary evidence suggests that because pyridoxine increases serotonin and gaba levels in the blood, it may benefit people in dysphoric mental states. well-designed clinical trials are needed to confirm potential benefit.	c

*Key to grades
A: Strong scientific evidence for this use;
B: Good scientific evidence for this use;
C: Unclear scientific evidence for this use;
D: Fair scientific evidence against this use;
F: Strong scientific evidence against this use.