Medical Condition Oral Aphthae

Source:

2009 icd-9-cm diagnosis 528.2 - oral aphthae

Active Ingredients used for Oral Aphthae:

Aloe, Licorice And Dgl, Propolis

Active Ingredient	Uses based on scientific evidence	Grade*
aloe (aloe vera)	there is weak evidence that treatment of recurrent aphthous ulcers of the mouth with aloe gel may reduce pain and increase the amount of time between the appearance of new ulcers. further study is needed before a firm recommendation can be made.	c
licorice (glycyrrhiza glabra l.) and dgl (deglycyrrhizinated licorice)	some research suggests that licorice extracts, dgl, and the drug carbenoxolone, may provide benefits for treating cankers sores. however, studies have been small with flaws in their designs. the safety of dgl makes it an attractive therapy if it does speed healing of these sores, but it is not clear at this time whether there is truly any benefit.	c
propolis	there is some evidence that propolis taken by mouth may help reduce outbreaks of canker sores. further research is needed to confirm this.	c

*Key to grades
A: Strong scientific evidence for this use;
B: Good scientific evidence for this use;
C: Unclear scientific evidence for this use;
D: Fair scientific evidence against this use;
F: Strong scientific evidence against this use.