Medical Condition Unspecified Adverse Effect Of Other Drug, Medicinal And Biological Substance

Source:

2009 icd-9-cm diagnosis 995.29 - unspecified adverse effect of other drug, medicinal and biological substance

Active Ingredients used for Unspecified Adverse Effect Of Other Drug Medicinal And Biological Substance:

Arginine, Ginkgo, Melatonin, Selenium, Vitamin A

Active Ingredient	Uses based on scientific evidence	Grade*
arginine (l-arginine)	early human studies suggest that arginine supplements may be beneficial for patients undergoing chemotherapy. larger, high-quality studies are needed.	c
ginkgo (ginkgo biloba l.)	in limited human study, ginkgo has been examined in addition to 5-fluorouracil (5-fu) in the treatment of pancreatic and colorectal cancer, to measure possible benefits on side effects. at this time, there is a lack of conclusive evidence in this area.	c
melatonin	several human trials have examined the effects of melatonin on side effects associated with various cancer chemotherapies. although these early reported benefits are promising, high-quality controlled trials are necessary before a clear conclusion can be reached in this area. it remains unclear if melatonin safely reduces side effects of various chemotherapies without altering effectiveness.	c
selenium (se)	study results of selenium supplementation during chemotherapy are mixed. general concern has been raised that antioxidants may interfere with radiation therapy or some chemotherapy agents, which themselves can depend on oxidative damage to tumor cells for anti-cancer activity. therefore, patients undergoing cancer treatment should speak with their oncologist and pharmacist before taking selenium supplements.	c
vitamin a (retinol)	vitamin a supplementation does not appear to improve chemotherapy-related side effects including nausea, vomiting, diarrhea, or mouth sores.	d

*Key to grades
A: Strong scientific evidence for this use;
B: Good scientific evidence for this use;
C: Unclear scientific evidence for this use;
D: Fair scientific evidence against this use;
F: Strong scientific evidence against this use.